49th Test and Evaluation Squadron

The 49th Test and Evaluation Squadron is an active United States Air Force unit. Its current assignment is with the 53d Wing, based at Barksdale Air Force Base, Louisiana.

During World War II, the 49th Bombardment Squadron was a B-17 Flying Fortress squadron, assigned to the 2d Bombardment Group, Fifteenth Air Force. It earned Two Distinguished Unit Citations.

Mission

The 49th Test and Evaluation Squadron is home to several bomber operational test programs. Primary among these are the Nuclear Weapon System Evaluation Program, the bomber portion of the Air to Ground Weapon System Evaluation Program, and initial operational test of the Joint Direct Attack Munition and the Wind Corrected Munitions Dispenser. The squadron is an Air Combat Command (ACC) unit tasked to support and conduct operational testing from all three Air Force bombers. The squadron’s main focus is on the B-52 with additional testing being conducted on the B-1 and B-2. To accomplish its mission, the squadron must use operational bombers as there are no test coded bombers in ACC.

TES (magazine)

TES, formerly known as the Times Educational Supplement, is a weekly UK publication aimed primarily at school teachers in the UK. It was first published in 1910 as a pull-out supplement in The Times newspaper. Such was its popularity that in 1914, the supplement became a separate publication selling for 1 penny.

TES focuses on school-related news and features. It covered higher education until the Times Higher Education Supplement (THE) was launched as a sister publication in 1971. Today its editor is Ann Mroz. Since 1964, an alternative version of the publication, TESS, has been produced for Scotland. An edition for Wales, TES Cymru, was also published between 2004 and 2011. All are produced by London-based company TES Global, which has been owned by US investment firm TPG Capital LLP since 2013.

TES is published weekly on Fridays, at a cover price of £1.90. Data from the National Readership Survey Jan–Dec 2012 suggests that the average yearly readership is around 362,000, of which around 90 per cent of the readership are in the ABC1 category.

Testin

Testin also known as TESS is a protein that in humans is encoded by the TES gene located on chromosome 7. TES is a 47 kDa protein composed of 421 amino acids found at focal adhesions and is thought to have a role in regulation of cell motility. In addition to this, TES functions as a tumour suppressor. The TES gene is located within a fragile region of chromosome 7, and the promoter elements of the TES gene have been shown to be susceptible to methylation - this prevents the expression of the TES protein. TES came to greater prominence towards the end of 2007 as a potential mechanism for its tumour suppressor function was published.

Domain organisation

Tes is composed of the following domains:

The structures of the Cysteine rich domain and the PET domain are not known. LIM domains, however, are known as modulators of protein interactions. LIM domain consist of 2 zinc fingers separated by 2 hydrophobic amino acids (generally a phenylalanine and then a leucine).

Binding partners

TES does not appear to be an enzyme; rather it is a protein that mediates/regulates cellular functions via Protein:protein interactions. Pull down experiments reveal that TES has putative interactions mediated by the indicated domain:

Man (Middle-earth)

In J. R. R. Tolkien's Middle-earth books, such as The Hobbit and The Lord of the Rings, the terms Man and Men refer to humankind – in contrast to Elves, Dwarves, Orcs and other humanoid races – and does not denote gender.

The Elves call the race of Men Atani in Quenya, literally meaning "Second People" (the Elves being the First), but also Hildor (Followers), Apanónar (After-born), and Fírimar or Firyar (Mortals). Less charitably they were called Engwar (The Sickly), owing to their susceptibility to disease and old age, and their generally unlovely appearance in the Elves' eyes. The name Atani becomes Edain in Sindarin, but this term is later applied only to those tribes of Men who are friendly to the Elves. Other names appear in Sindarin as Aphadrim, Eboennin, and Firebrim or Firiath.

Origins

The race of Men is the second race of beings created by the One God, Ilúvatar. Because they awoke at the start of the Years of the Sun, while the Elves awoke at the start of the First Age during the Years of the Trees, they are called the Afterborn by the Elves.

Manú (footballer)

Emanuel Jesus Bonfim Evaristo (born 28 August 1982), known as Manú, is a Portuguese professional footballer who plays mainly as a right winger.

Club career

Born in Setúbal, Manú started his professional career in the 2001–02 season playing for F.C. Alverca, before signing for S.L. Benfica in 2004 on a four-year contract. He was immediately loaned after arriving, serving stints in Italian sides Modena F.C. and A.C. Carpenedolo to gain experience, and returned to Portugal in the 2005–06 campaign for another temporary spell with C.F. Estrela da Amadora, where he played in 31 league games and scored seven goals, contributing to the preservation of the side's first division status.

In June 2006 Manú was given a new four-year deal and made his official debut for the Eagles by playing in both legs of the UEFA Champions League third qualifying round win against FK Austria Wien, also making a substitute appearance for Benfica in the group stages against F.C. Copenhagen, on 13 September 2006 (0–0 away draw).

José Manuel Jiménez Ortiz

José Manuel Jiménez Ortiz (born 21 December 1981), known as Mané, is a Spanish footballer who plays as a left back.

Football career

Born in Tarifa, Province of Cádiz, Mané started playing professional football with lowly Real Balompédica Linense and CD Díter Zafra, being limited to just eight third division games with the latter. In 2003 he moved to Atlético Madrid B, in the same category.

In the 2005–06 season Mané progressed to the second level, joining Ciudad de Murcia and appearing in 39 league games (with two goals). The following campaign he moved clubs again, this time to UD Almería: he quickly became first-choice, being instrumental in the side's first ever promotion to La Liga.

Mané's Almería performances were much admired over the course of 2007–08, represented by him being named in Sky Sports pundit Guillem Balagué's team of the season, as the Andalusians overachieved and finished eighth with the player scoring twice, in 1–1 draws with RCD Mallorca and Recreativo de Huelva.